Knowledge Management System Of Guangzhou Institute of Geochemistry，CAS
Huang, Chenchen1,2,3; Hu, Keqi1,2,4; Zeng, Yanhong1,2,4; Jiang, Yiye1,2,5; Tian, Yankuan1,2,4; Luo, Xiaojun1,2,4 ; Mai, Bixian1,2
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| In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities | |
| Source Publication | SCIENCE OF THE TOTAL ENVIRONMENT
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| ISSN | 0048-9697 |
| 2023-03-15 | |
| Volume | 864Pages:10 |
| DOI | 10.1016/j.scitotenv.2022.161043 |
| Language | 英语 |
| WOS Research Area | Environmental Sciences & Ecology |
| Abstract | In this study, the biotransformation behavior and potential nuclear receptor affinities of polychlorinated biphenyls (PCBs) with different chlorine-substituted structures (PCB 77/110/136/174) were explored using human and rat liver microsomes (HLM and RLM). The rate constants (kobs) of PCBs showed the variations in the order patterns for the HLM (PCB 136 > PCB 110 > PCB 174 > PCB 77) and RLM (PCB 110 > PCB 136 > PCB 174 > PCB 77). However, studied PCBs showed similar metabolite profiles and enantioselective of PCBs between HLM and RLM. The Mono-OH -PCBs were the major metabolites of PCB 77/174, whereas mono -OH-and di-OH-PCBs were the major metabolites of PCB 110/136 for the HLM and RLM, indicating that OH-PCBs could be further oxidized. Enantiomeric enrichment of (-)-PCB 136 and (+)-PCB 174 was observed in microsomal metabolism. Moreover, the inflection point of the enan-tiomer fraction for PCB 136 metabolized by the HLM suggests a competitive metabolism between individual atropisomers. Furthermore, molecular docking results demonstrated the relatively high affinity between PCBs (or OH-PCBs) and certain nuclear receptors, indicating that abnormal metabolic enzyme expression and endocrine disruption occur in PCB-exposed humans. |
| Keyword | Hepatic metabolism Polychlorinated biphenyls Human Rat Nuclear receptor affinities |
| WOS ID | WOS:000921555300001 |
| Indexed By | SCI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.gig.ac.cn/handle/344008/72508 |
| Collection | 有机地球化学国家重点实验室 |
| Corresponding Author | Zeng, Yanhong |
| Affiliation | 1.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Protect & Resources Uti, Guangzhou 510640, Peoples R China 3.China Univ Min & Technol, Sch Environm Sci & Spatial Informat, Xuzhou 221116, Jiangsu, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Hong Kong MaCao Joint Lab Environm Pollu, Hong Kong 510640, Guangdong, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Huang, Chenchen,Hu, Keqi,Zeng, Yanhong,et al. In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,864:10. |
| APA | Huang, Chenchen.,Hu, Keqi.,Zeng, Yanhong.,Jiang, Yiye.,Tian, Yankuan.,...&Mai, Bixian.(2023).In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities.SCIENCE OF THE TOTAL ENVIRONMENT,864,10. |
| MLA | Huang, Chenchen,et al."In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities".SCIENCE OF THE TOTAL ENVIRONMENT 864(2023):10. |
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