Knowledge Management System Of Guangzhou Institute of Geochemistry，CAS
| Zhang, Jin-Na1,3,4; Gong, Xiao-Fan1,2; Ying, Guang-guo3,4; Wang, An-Guo1,5; Dong, Mei-Jun1; Liu, You-sheng3,4; Deng, Tong -Chu1; Xu, Mei-Ying1 | |
| Innovative bioremediation of dexamethasone in aquatic ecosystems using Rhodococcus sp. D32: Pathway discovery and reduction of ecotoxicity | |
| Source Publication | JOURNAL OF CLEANER PRODUCTION
 |
| ISSN | 0959-6526 |
| 2024-03-10 | |
| Volume | 444Pages:10 |
| DOI | 10.1016/j.jclepro.2024.141319 |
| Language | 英语 |
| WOS Research Area | Science & Technology - Other Topics ; Engineering ; Environmental Sciences & Ecology |
| Abstract | In response to the widespread environmental concern of endocrine disruptors, our research investigated the aerobic biodegradation of dexamethasone (DEX), a widely used synthetic glucocorticoid with endocrinedisrupting properties, by strain Rhodococcus sp. D32. This innovative strain showcases remarkable DEXdegrading capabilities, with the half-life for degrading 500 mu g/L DEX in MH broth being just 7.56 h. Utilizing high -resolution mass spectrometry, we identified six transformation products (TPs) and revealed a unique steroid nucleus -opening pathway marked by A -ring lactonization and subsequent lactone hydrolysis. This newly discovered pathway deviates from the classical steroid 9,10-seco pathways and previous transformations that preserved the intact steroid nucleus, thus expanding our knowledge of microbial steroid transformations. Additionally, the degradation process progressively converts the parent DEX into less ecotoxic products, significantly reducing the overall ecotoxicity of the system. This reduction remains evident when considering the combined toxicity of DEX and its TPs, indicating a promising approach for lessening environmental harm. Strain D32 also proved effective in various authentic aquatic environments, including fishpond water, urban sewage, river water, and reservoir water, where its introduction markedly expedited the dissipation of DEX. Our findings underscore the potential of strain D32 as a powerful tool for the bioremediation of DEX, presenting an efficient and eco-friendly strategy to alleviate the effects of this endocrine disruptor in aquatic ecosystems. |
| Keyword | Dexamethasone Rhodococcus sp. Biodegradation Transformation pathways High -resolution mass spectrometry Ecotoxicity reduction |
| WOS ID | WOS:001202697000001 |
| Indexed By | SCI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.gig.ac.cn/handle/344008/77122 |
| Collection | 有机地球化学国家重点实验室 |
| Corresponding Author | Xu, Mei-Ying |
| Affiliation | 1.Guangdong Acad Sci, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Inst Microbiol,Guangdong Environm Protect Key Lab, Guangzhou 510070, Peoples R China 2.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China 3.South China Normal Univ, SCNU Environm Res Inst, Guangdong Prov Key Lab Chem Pollut & Environm Saf, Guangzhou 510006, Peoples R China 4.South China Normal Univ, MOE Key Lab Environm Theoret Chem, Guangzhou 510006, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Jin-Na,Gong, Xiao-Fan,Ying, Guang-guo,et al. Innovative bioremediation of dexamethasone in aquatic ecosystems using Rhodococcus sp. D32: Pathway discovery and reduction of ecotoxicity[J]. JOURNAL OF CLEANER PRODUCTION,2024,444:10. |
| APA | Zhang, Jin-Na.,Gong, Xiao-Fan.,Ying, Guang-guo.,Wang, An-Guo.,Dong, Mei-Jun.,...&Xu, Mei-Ying.(2024).Innovative bioremediation of dexamethasone in aquatic ecosystems using Rhodococcus sp. D32: Pathway discovery and reduction of ecotoxicity.JOURNAL OF CLEANER PRODUCTION,444,10. |
| MLA | Zhang, Jin-Na,et al."Innovative bioremediation of dexamethasone in aquatic ecosystems using Rhodococcus sp. D32: Pathway discovery and reduction of ecotoxicity".JOURNAL OF CLEANER PRODUCTION 444(2024):10. |
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