Melanin-mediated accumulation of polycyclic aromatic hydrocarbons in human hair: Insights from biomonitoring and cell exposure studies

doi:10.1016/j.jhazmat.2024.134112

	Zhang, Shiyi 1; Luo, Weikeng 1,3; Zhao, Fang 1,2,3; Huang, Lulu 1,2; Qin, Ruixin 1,4; Yan, Xiao 1; Tang, Bin 1; Luo, Xiaojun4,5,6 ; Mai, Bixian4,5,6 ; Yu, Yunjiang 1; Zheng, Jing 1
	Melanin-mediated accumulation of polycyclic aromatic hydrocarbons in human hair: Insights from biomonitoring and cell exposure studies
刊名	JOURNAL OF HAZARDOUS MATERIALS
ISSN号	0304-3894
	2024-05-15
卷号	470 页码:8
DOI	10.1016/j.jhazmat.2024.134112
语种	英语
WOS研究方向	Engineering ; Environmental Sciences & Ecology
摘要	While human hair is widely used to monitor micro-organic contaminants (MOCs), their incorporation mechanisms are poorly understood. Melanin, known to facilitate the accumulation of drugs in hair, hasn't been studied in the field of MOCs. Here, polycyclic aromatic hydrocarbons (PAHs), a class of priority MOCs, were investigated through hair biomonitoring as well as cell exposure experiments. PAH concentrations and melanin contents were measured in black and white hairs from the same individual. The results showed that five dominant PAHs (phenanthrene, fluoranthene, pyrene, benzo[a]anthracene and chrysene) in black hair (0.66 ng/g - 35.1 ng/g) were significantly higher than those in white hair (0.52 ng/g - 29.6 ng/g). Melanin contents in black hair (14.9 - 48.9 ng/g) were markedly higher than in white hair (0.35 - 2.15 ng/g) and were correlated to PAH concentrations, hinting melanin-mediated accumulation of PAHs in hair. The in vitro experiment using murine melanoma cells demonstrates that PAH levels in cells were affected by melanin, suggesting the affinity of melanin to PAHs. Both biomonitoring and cell exposure experiment implicate the pivotal role of melanin in PAH accumulation in hair. Therefore, to ensure the accuracy of hair biomonitoring for MOCs, attention must be paid to the melanin content uniformity.
关键词	Hair Biomonitoring PAHs Melanin Accumulation mechanism
WOS记录号	WOS:001222815100001
收录类别	SCI
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.gig.ac.cn/handle/344008/76931
专题	有机地球化学国家重点实验室
通讯作者	Luo, Weikeng; Zheng, Jing
作者单位	1.Minist Ecol & Environm, South China Inst Environm Sci, Res Ctr Emerging Contaminants, State Environm Protect Key Lab Environm Pollut Hlt, Guangzhou 510655, Peoples R China 2.South China Normal Univ, Sch Environm, Guangdong Prov Key Lab Chem Pollut & Environm Safe, Guangzhou 510006, Peoples R China 3.South China Normal Univ, MOE Key Lab Theoret Chem Environm, Guangzhou 510006, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & Pr, Guangzhou 510640, Peoples R China 6.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Hong Kong Macao Joint Lab Environm Pollu, Hong Kong 510640, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shiyi,Luo, Weikeng,Zhao, Fang,et al. Melanin-mediated accumulation of polycyclic aromatic hydrocarbons in human hair: Insights from biomonitoring and cell exposure studies[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,470:8.
APA	Zhang, Shiyi.,Luo, Weikeng.,Zhao, Fang.,Huang, Lulu.,Qin, Ruixin.,...&Zheng, Jing.(2024).Melanin-mediated accumulation of polycyclic aromatic hydrocarbons in human hair: Insights from biomonitoring and cell exposure studies.JOURNAL OF HAZARDOUS MATERIALS,470,8.
MLA	Zhang, Shiyi,et al."Melanin-mediated accumulation of polycyclic aromatic hydrocarbons in human hair: Insights from biomonitoring and cell exposure studies".JOURNAL OF HAZARDOUS MATERIALS 470(2024):8.