Knowledge Management System Of Guangzhou Institute of Geochemistry，CAS
| Poddar, Arunava1,2; Satthiyasilan, Nirmell3; Wang, Po-Hsiang4,5; Chen, Chen6,7; Yi, Ruiqin8; Chandru, Kuhan3,9; Jia, Tony Z.1,6 | |
| Reactions Driven by Primitive Nonbiological Polyesters | |
| Source Publication | ACCOUNTS OF CHEMICAL RESEARCH
 |
| ISSN | 0001-4842 |
| 2024-07-16 | |
| Pages | 10 |
| DOI | 10.1021/acs.accounts.4c00167 |
| Language | 英语 |
| WOS Research Area | Chemistry |
| Abstract | All life on Earth is composed of cells, which are built from and run by biological reactions and structures. These reactions and structures are generally the result of action by cellular biomolecules, which are indispensable for the function and survival of all living organisms. Specifically, biological catalysis, namely by protein enzymes, but also by other biomolecules including nucleic acids, is an essential component of life. How the biomolecules themselves that perform biological catalysis came to exist in the first place is a major unanswered question that plagues researchers to this day, which is generally the focus of the origins of life (OoL) research field. Based on current knowledge, it is generally postulated that early Earth was full of a myriad of different chemicals, and that these chemicals reacted in specific ways that led to the emergence of biochemistry, cells, and later, life. In particular, a significant part of OoL research focuses on the synthesis, evolution, and function of biomolecules potentially present under early Earth conditions, as a way to understand their eventual transition into modern life. However, this narrative overlooks possibilities that other molecules contributed to the OoL, as while biomolecules that led to life were certainly present on early Earth, at the same time, other molecules that may not have strict, direct biological lineage were also widely and abundantly present. For example, hydroxy acids, although playing a role in metabolism or as parts of certain biological structures, are not generally considered to be as essential to modern biology as amino acids (a chemically similar monomer), and thus research in the OoL field tends to perhaps focus more on amino acids than hydroxy acids. However, their likely abundance on early Earth coupled with their ability to spontaneously condense into polymers (i.e., polyesters) make hydroxy acids, and their subsequent products, functions, and reactions, a reasonable target of investigation for prebiotic chemists. Whether "non-biological" hydroxy acids or polyesters can contribute to the emergence of life on early Earth is an inquiry that deserves attention within the OoL community, as this knowledge can also contribute to our understanding of the plausibility of extraterrestrial life that does not exactly use the biochemical set found in terrestrial organisms. While some demonstrations have been made with respect to compartment assembly, compartmentalization, and growth of primitive polyester-based systems, whether these "non-biological" polymers can contribute any catalytic function and/or drive primitive reactions is still an important step toward the development of early life. Here, we review research both from the OoL field as well as from industry and applied sciences regarding potential catalysis or reaction driven by "non-biological" polyesters in various forms: as linear polymers, as hyperbranched polyesters, and as membraneless microdroplets. |
| WOS ID | WOS:001270036100001 |
| Indexed By | SCI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.gig.ac.cn/handle/344008/72352 |
| Collection | 中国科学院广州地球化学研究所 |
| Corresponding Author | Chandru, Kuhan; Jia, Tony Z. |
| Affiliation | 1.Blue Marble Space Inst Sci, Seattle, WA 98104 USA 2.Univ Basque Country, Res Ctr Expt Marine Biol & Biotechnol PiE UPV EHU, Bizkaia 48620, Basque Country, Spain 3.Natl Univ Malaysia, Inst Climate Change, Space Sci Ctr ANGKASA, Bandar Baru Bangi 43600, Selangor, Malaysia 4.Natl Cent Univ, Grad Inst Environm Engn, Taoyuan 32001, Taiwan 5.Natl Cent Univ, Dept Chem & Mat Engn, Taoyuan 32001, Taiwan 6.Tokyo Inst Technol, Earth Life Sci Inst, Tokyo 1528550, Japan 7.RIKEN Ctr Sustainable Resource Sci CSRS, Biofunct Catalyst Res Team, 2-1 Hirosawa, Wako, Saitama 3510198, Japan 8.Chinese Acad Sci, Guangzhou Inst Geochem, CAS Ctr Excellence Deep Earth Sci, State Key Lab Isotope Geochem, Guangzhou 510640, Peoples R China 9.Univ Kebangsaan Malaysia, Fac Sci & Technol, Polymer Res Ctr PORCE, Bandar Baru Bangi 43600, Selangor, Malaysia |
| Recommended Citation GB/T 7714 | Poddar, Arunava,Satthiyasilan, Nirmell,Wang, Po-Hsiang,et al. Reactions Driven by Primitive Nonbiological Polyesters[J]. ACCOUNTS OF CHEMICAL RESEARCH,2024:10. |
| APA | Poddar, Arunava.,Satthiyasilan, Nirmell.,Wang, Po-Hsiang.,Chen, Chen.,Yi, Ruiqin.,...&Jia, Tony Z..(2024).Reactions Driven by Primitive Nonbiological Polyesters.ACCOUNTS OF CHEMICAL RESEARCH,10. |
| MLA | Poddar, Arunava,et al."Reactions Driven by Primitive Nonbiological Polyesters".ACCOUNTS OF CHEMICAL RESEARCH (2024):10. |
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